Endocrine Abstracts

Background of Study: Some medications for the treatment of type 2 diabetes mellitus fail to achieve a continuous favorable glucose control in the long run during clinical use. Therefore we examined the durability of dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin which is relatively new to Japanese type 2 diabetic patients in clinical settings.Objectives and Methods: 117 subjects (M/F=65/52, Age: 66±10 y.o., duration of diabetes 12±8 y. b...

Introduction: Postoperative sepsis exhibits high mortality. Prevention of postoperative infection and palliation of sepsis symptom are important issues in the patient’s care after surgical operation. Adipose tissue as an endocrine organ that secretes various cytokines. Circulating adiponectin, an anti-inflammatory cytokine, and inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α are derived partially from adipose tissues. Recent studie...

The testis and epididymis collaborate in the male gamete development. The testis has the specific function to generate spermatozoa and spermatozoa undergo numerous changes passing through the epididymis. p63 in the basal layer of epithelium plays a key role in maintaining cellular populations, whereas Notch 1 and its ligand Jagged 2 have an important role in the cell differentiation and Jagged 2 is up-regulated by TAp63, which transactivates p53 target genes and induces apopto...

The pulse mode of gonadotrophin-releasing hormone (GnRH) release from the hypothalamus and following luteinising hormone (LH) pulses from the pituitary induce follicular development in female animals. Kisspeptin neurons in the hypothalamic arcuate nucleus (ARC) are suggested to be the GnRH pulse generator. Adrenomedullin (AM) is a secretory peptide expressed in various tissues, including the hypothalamic paraventricular nucleus, but its functions in the central regulation of r...

Background and objective: Sleep disorders (SDs) are classified into subjective and objective SDs, and subjective SDs are directly related to quality of life. According to previous studies, Graves’ disease (GD) causes SDs, especially insomnia. However, the characteristics of subjective SDs and its clinical course after hyperthyroidism normalization remain unclear. Additionally, the factors involved in subjective SDs with hyperthyroidism in GD remain unclear. Hyperthyroidis...